The third and final expansion, Repentance, was released in March 2021. Afterbirth and Afterbirth+, in October 2015 and January 2017, respectively, with more game content and gameplay modes Afterbirth+ also added support for user-created content. This platform had limitations and led McMillen to work with Nicalis to produce Rebirth with a more advanced game engine, which in turn enabled the substantial addition of new content and gameplay features.

Rebirth is a remake of The Binding of Isaac, which was developed by McMillen and Florian Himsl and released in 2011 as an Adobe Flash application. The PlayStation 5 and Xbox Series X/S versions were released in November 2021. Rebirth was released for Linux, Microsoft Windows, OS X, PlayStation 4 and PlayStation Vita in November 2014, for Xbox One, New Nintendo 3DS and Wii U in July 2015, for iOS in January 2017 and for Nintendo Switch in March 2017. The Binding of Isaac: Rebirth is an indie roguelike video game designed by Edmund McMillen and developed and published by Nicalis.

The lost binding of isaac